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Body composition and basal metabolic rate in Hidradenitis Suppurativa: a Danish population‐based and hospital‐based cross‐sectional study
Author(s) -
Miller I.M.,
Rytgaard H.,
Mogensen U.B.,
Miller E.,
Ring H.C.,
Ellervik C.,
Jemec G.B.
Publication year - 2016
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.13522
Subject(s) - medicine , bioelectrical impedance analysis , hidradenitis suppurativa , body mass index , basal metabolic rate , waist , population , obesity , classification of obesity , cross sectional study , body fat percentage , abdominal obesity , endocrinology , physiology , fat mass , pathology , disease , environmental health
Background Several studies have suggested an association between Hidradenitis Suppurativa (HS) and obesity. Obesity is often expressed as Body Mass Index ( BMI ). However, BMI lacks information on body composition. General obesity is a predictor of health status and cardiovascular risk, but body composition (e.g. abdominal fat) may be more so. Basal metabolic rate ( BMR ) is an expression of resting metabolism and may serve as a complementary tool when assessing the possibly underlying metabolism behind a persons' body composition. Objective To investigate the body composition and basal metabolic rate in individuals with HS compared with healthy controls. Methods We performed a cross‐sectional study on both a hospital‐based and population‐based HS group and compared with controls using Bioelectrical Impedance Analysis to assess body composition. Results We identified a hospital‐based HS group of 32 hospital HS patients, a population‐based HS group of 430 population HS patients, and 20 780 controls. Age‐ and sex‐adjusted analyses showed a 10.12% ( P < 0.0001) significantly higher fat percentage in the hospital‐based HS group and 3.11% ( P < 0.0001) significantly higher fat percentage for the population‐based HS group compared to controls. Correspondingly, the HS groups had a lower muscle percentage ( P < 0.0001) and lower bone mass percentage ( P < 0.0001). Furthermore, visceral fat rating ( P < 0.0001), Body Mass Index ( P < 0.0001), waist circumference ( P < 0.0001), and Waist/Hip Ratio ( P < 0.0001) was significantly higher in HS patients compared with controls. Additionally, age and sex‐adjusted analyses showed a higher predicted estimate of BMR for the HS groups compared with controls (154.56 kcal/day (95% CI 54.96–254.16) ( P = 0.0031) for the hospital‐based HS group, and 82.63 kcal/day (95% CI 59.70–105.56) ( P < 0.0001) for the population‐based HS group). Conclusion Hidradenitis Suppurativa is associated with a high fat percentage, high visceral fat, and low muscle percentage adding to the morbidity of HS . The higher predicted estimate of basal metabolic rate ( BMR ) in HS patients may reflect a dysfunctional metabolism contributing to the high‐fat‐body composition.