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Genital melanocytic naevus on lichen sclerosus: an uncommon occurrence and a management proposal
Author(s) -
Neri I.,
Dika E.,
Fanti P.A.,
Misciali C.,
Patrizi A.
Publication year - 2016
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.13115
Subject(s) - medicine , lichen sclerosus , dermatology , sex organ , melanocytic nevus , nevus , melanoma , genetics , biology , cancer research
Background Melanocytic naevi located in special sites, such as the vulvar mucosa might present peculiar clinical and dermatoscopic features. Objectives We describe a management proposal of a genital naevus associated with inflammatory disorders that aims to facilitate the clinical and pathologic diagnosis. Methods Videodermoscopy of a genital naevus associated with lichen sclerosus of an 8‐year‐old girl, was carried out before and 2 months after treatment with topical steroids. An excisional biopsy and immunohistochemical studies with HMB ‐45, MART ‐1 and molecular studies with p 16 staining were performed. Results The features of the melanocytic lesion associated with lichen sclerosus were troublesome on the basis of clinical and videodermoscopic evaluation. Histopathologic and immunohistochemical examination performed after topical treatment, showed a compound melanocytic naevus with an underlying inflammation consistent with lichen sclerosus. Conclusions The evaluation of genital naevi should take into account the presence of inflammatory disorders, not uncommon in such location. Treatment of the latter and short follow‐up of the patients, can avoid over‐diagnosis of malignancies and extensive surgical procedures.