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Reflectance confocal microscopy for the diagnosis of vulvar naevi: six cases
Author(s) -
Cinotti E.,
Couzan C.,
Perrot J.L.,
Labeille B.,
Bahadoran P.,
Puig S.,
Wantz M.,
VicenteVilla A.,
Habougit C.,
Butori C.,
Cambazard F.
Publication year - 2016
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12924
Subject(s) - medicine , atypia , pathology , dermatology , differential diagnosis , malignancy , nevus , confocal , vulva , vulvar neoplasm , vulvar intraepithelial neoplasia , melanoma , mathematics , cancer research , geometry
Background and objectives The differential diagnosis between vulvar naevi and melanoma is challenging. In vivo reflectance‐mode confocal microscopy ( RCM ) is an emerging technique that allows non‐invasive high‐resolution imaging of the skin and mucosa. It has recently been used for the study of vulvar melanosis and melanoma, but it has not been so far employed for the diagnosis of genital naevi. The objective of this study is to evaluate RCM features of vulvar naevi and to compare them with dermoscopical and histopathological aspects. Methods Clinical, dermoscopical, in vivo RCM and histological features of six vulvar naevi were evaluated. Results The clinical and/or dermoscopical aspects were suspicious in all six cases. RCM showed a blue naevus, an atypical genital naevus, a junctional naevus and three compound naevi that were later confirmed by histological examination. In one compound naevus, RCM showed focal cytological atypia and architectural irregularity without clear features of malignancy, confirmed by histological examination. Conclusions Reflectance‐mode confocal microscopy can play a role in non‐invasive diagnosis of vulvar naevi, but further broader studies are required to validate our observations.