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T H 17 cells, interleukin‐17 and interferon‐ γ in patients and households contacts of leprosy with multibacillary and paucibacillary forms before and after the start of chemotherapy treatment
Author(s) -
AlmeidaNeto F.B.,
Assis Costa V.M.,
OliveiraFilho A.F.,
Souza Franco E.,
Tavares Julião de Lima E.V.,
Barros de Lorena V.M.,
Oliveira de Souza V.M.,
Sousa Maia M.B.
Publication year - 2015
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12869
Subject(s) - medicine , leprosy , immunology , immune system , interleukin 17 , interleukin , interleukin 4 , disease , interferon , immunity , interleukin 2 , lymphocyte subsets , cytokine , interferon gamma , t cell
Background Studies on the immunology of leprosy are fundamental to the understanding of the various forms of clinical manifestation of the disease. In some diseases, lymphocytes T H 17 and one of its key cytokines, interleukin‐17 has been shown to be essential in developing an effective immune response. In leprosy, involvement of lymphocyte T H 17 and interleukin‐17 remains understudied. Objectives This study is the first investigation to examine the association between T H 17 cells, interleukin‐17 and interferon‐ γ in patients and households contacts of leprosy. Methods To document the participation of T H 17 cells and interleukin‐17 in the immunology of leprosy, to observe the behavior of interferon‐γ in relation to interleukin‐17 and to verify the differences found between individuals paucibacillary, multibacillary and household contacts, we analyzed samples peripheral blood to identify T H ‐17 cells, interleukin‐17 and IFN ‐γ; establishing relationships between all the groups. Results There was a significant difference in the results found in the comparison between the paucibacillary and multibacillary groups of patients ( P < 0.001), as well with the household contacts ( P < 0.005). The polychemotherapeutic treatment modified the profile of immune response in multibacillary patients compared to what was observed before the start of treatment. Conclusion The principal finding was that T H 17 lymphocytes and interleukin‐17 actively participating in the immune response of H ansen's disease as well these cells can stimulate the cellular immunity.