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Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised patients
Author(s) -
Stimpfle D.W.,
Serra A.L.,
Wüthrich R.P.,
French L.E.,
Braun R.P.,
Hofbauer G.F.L.
Publication year - 2015
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12771
Subject(s) - medicine , immunosuppression , skin cancer , skin type , melanoma , dermatology , gastroenterology , cancer , cancer research
Background SIA scopy (Spectrophotometric Intracutaneous Analysis) enables non‐invasive analysis of the skin. Objective We wanted to determine whether SIA scopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for non‐melanoma skin cancer ( NMSC ). Methods Volunteers and patients were measured by SIA scopy at six spots on sun‐exposed and two spots on sun‐protected skin. Measurements were transformed by SIA metrics into arbitrary units and statistically analysed. Results Melanin was shown to be higher with age (+1.73759 a.u.; P < 0.0001), sun exposure (+47.03998 a.u.; P < 0.0001), immunosuppression (+10.48526 a.u.; P < 0.0001) and lower in males (−26.50952 a.u.; P < 0.0001). Collagen was lower with increasing age (−0.29162 a.u.; P < 0.0001) and sun exposure (−6.85586 a.u.; P < 0.0001) but higher with male sex (+8.34251 a.u.; P < 0.0001) and immunosuppression (+5.79171 a.u.; P = 0.0001). Haemoglobin was lower with increasing age (−0.23833 a.u.; P = 0.0005), but higher with male sex (+18.51976 a.u.; P < 0.0001) and sun exposure (+13.74523 a.u.; P < 0.0001). Haemoglobin content was not associated to immunosuppression. Conclusion Our results encourage the use of SIA scopy as a tool to better gauge an individual patient's NMSC risk factors. Further studies should help to better delineate SIA scopy as a prognostic tool.