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Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus
Author(s) -
Cinotti E.,
Merlo V.,
Kempf W.,
Carli C.,
Kanitakis J.,
Parodi A.,
Rongioletti F.
Publication year - 2015
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12654
Subject(s) - medicine , mucin , reticular connective tissue , pathology , immunohistochemistry , mucinosis , dermatology
Abstract Background and objectives Reticular erythematous mucinosis ( REM ) and lupus erythematosus tumidus ( LET ) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of REM and LET . Methods We evaluated epidermal thickness, hyperkeratosis, dermo‐epidermal junction changes, interstitial mucin deposition, vessel dilatation and pattern, type and density of the inflammatory infiltrate in 25 cases of REM and LET . Anti‐ CD 3, anti‐ CD 20, anti‐ CD 68, anti‐ CD 4, anti‐ CD 8, anti‐ CD 123, anti‐ CD 2 AP , anti‐IgG and anti‐C3 antibodies were tested in a subset of patients. Results Both diseases are characterized by perivascular dermal infiltrates of lymphocytes mainly CD 4+ positive and increased dermal mucin. However, REM tended to show more scattered and more superficial lymphocytes with more superficial mucin and to have less frequent immunoglobulin and complement depositions along the dermo‐epidermal junction. Plasmacytoid dendritic cells ( PDC s) were less represented in REM , and were mainly found as single cells differently from LET . Conclusions REM and LET present some differences in the infiltrate, including PDC s, the mucin deposition and the immunoreactant deposition at the dermo‐epidermal junction that justify the distinction of the two diseases and suggest different pathogenetic mechanisms.