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Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficacies
Author(s) -
Yazdani Abyaneh M.,
Griffith R.D.,
FaltoAizpurua L.,
Nouri K.
Publication year - 2014
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12619
Subject(s) - vitiligo , medicine , ultraviolet b , dermatology , calcineurin , disease , population , ultraviolet therapy , psoriasis , transplantation , environmental health
Vitiligo is a disorder of pigmentation affecting about 1% of the global population. It is a psychologically devastating disease with suboptimal treatment options. Narrowband ultraviolet B ( NB ‐ UVB ) phototherapy has become a first‐line choice for treating generalized disease. In recent years, topical calcineurin inhibitors, vitamin D analogues, antioxidant agents and other therapies have been combined with NB ‐ UVB to improve its efficacy. This article will address what is known about the mechanisms of action of these treatments and how they may complement NB ‐ UVB on a cellular level, as well as offer a comprehensive, evidence‐based review of clinical outcomes with combination therapies.