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Gene expression profile of dermal mesenchymal stem cells from patients with psoriasis
Author(s) -
Hou R.,
Yan H.,
Niu X.,
Chang W.,
An P.,
Wang C.,
Yang Y.,
Yan X.,
Li J.,
Liu R.,
Li X.,
Zhang K.
Publication year - 2014
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12420
Subject(s) - psoriasis , mesenchymal stem cell , medicine , angiogenesis , vascular endothelial growth factor , gene expression , cancer research , immune system , immunology , pathology , gene , biology , vegf receptors , genetics
Background Mesenchymal stem cells ( MSC s) are likely involved in pathological processes of immune‐related diseases, including psoriasis because of their immunoregulatory and pro‐angiogenic effects, and the vascular proliferation, angiectasis and perivascular lymphocyte infiltration are known to be predominantly responsible for the pathological alterations in psoriasis. Objective This study aimed to investigate the gene expression profile of dermal MSC s from patients with psoriasis. Methods We isolated and expanded dermal MSC s from psoriatic patients and normal controls by using the attachment assay and conducted mRNA expression profile and gene ontology analyses using microarray. Results The gene expression profile of MSC s from psoriatic derma was markedly different from the normal derma‐derived MSC s; the angiogenesis‐related genes such as vascular endothelial growth factor A, insulin‐like growth factor‐binding protein‐5, and GATA 6 showed significant differential expression. Conclusions These results indicate that MSC s from the derma of psoriasis patients might be involved in the early development of psoriasis because of their pro‐angiogenic potential as well as the immunoregulatory effect.