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Association of autoimmune diseases with oral lichen planus: a cross‐sectional, clinical study
Author(s) -
LópezJornet P.,
ParraPerez F.,
PonsFuster A.
Publication year - 2014
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12202
Subject(s) - medicine , oral lichen planus , autoimmune disease , odds ratio , logistic regression , disease , cross sectional study , confidence interval , case control study , immunology , dermatology , pathology
Background The aim of this study was to investigate the association between autoimmune disease and oral lichen planus ( OLP ), comparing OLP patients with a control population. Methods This cross‐sectional clinical study evaluated the prevalence of autoimmune diseases in male and female patients with OLP . The variables analysed were age, sex, tobacco and alcohol consumption, the clinical form of OLP , time of evolution and the presence of autoimmune diseases. Results Autoimmune diseases were present in 7% of OLP patients (10/130) and 4% of the control group (6/130) without statistically significant difference ( P = 0.67). The estimated odds ratios (with 95% confidence intervals) of the presence of autoimmune disease in OLP sufferers was 1.033 (0.97–1.10). A logistic regression model for presence/absence of the risk autoimmune disease found statistically significant differences in relation to age. Conclusions At present, there is no definitive hypothesis that explains the coexistence of OLP and autoimmune disease; further research is required into the mechanisms whereby this coexistence occurs.