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Disease characteristics in patients with and without psoriatic arthritis treated with etanercept
Author(s) -
Papp K.,
Poulin Y.,
Vieira A.,
Shelton J.,
PoulinCostello M.
Publication year - 2014
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12138
Subject(s) - medicine , etanercept , dermatology life quality index , psoriatic arthritis , psoriasis , quality of life (healthcare) , psoriasis area and severity index , placebo , physical therapy , depression (economics) , arthritis , disease , dermatology , rheumatoid arthritis , pathology , alternative medicine , nursing , macroeconomics , economics
Background Patients with psoriasis (PsO) and psoriatic arthritis (PsA) have functional disability, pain and emotional problems, and experience lower quality of life (QoL) than patients with PsO alone. Objectives Examine effectiveness of etanercept ( ETN ) in patients with PsO alone, and with PsA, and determine whether PsA patients on ETN experience rapid QoL improvement. Methods Data from three phase III trials using ETN in adults with moderate‐to‐severe PsO were pooled. Patients with ( n = 523) and without ( n = 1330) PsA received ETN 25 mg once weekly to 50 mg twice weekly or placebo for 12–24 weeks. Assessments included Psoriasis Area and Severity Index ( PASI ), Dermatology Life Quality Index ( DLQI ), EuroQoL‐5D ( EQ ‐5D), Study 36‐item Short Form Health Survey ( SF ‐36) and Hamilton Depression Rating Scale ( HAM ‐D). Results Baseline PASI , EQ ‐5D and SF ‐36 physical component summary scores were worse for PsA patients. With ETN , PASI for PsA and non‐PsA groups improved as early as week 2. Scores for both groups converged by week 12. EQ ‐5D and SF ‐36 physical component improved faster in PsA patients, with EQ ‐5D scores converged by week 2. For total DLQI and most components, both groups had similar baseline scores and improved over 24 weeks on ETN . While the PsA group had more depressed patients at baseline, after 24 weeks on ETN it showed a greater reduction in the number of depressed patients than the non‐PsA group. Conclusions In patients with PsO involving ≥10% of body surface area, skin disease and QoL are worse in PsA patients. With ETN , QoL improved rapidly in PsA patients.