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The efficacy of single dose ivermectin in the treatment of hookworm related cutaneous larva migrans varies depending on the clinical presentation
Author(s) -
Vanhaecke C.,
Perig A.,
Monsel G.,
Regnier S.,
Bricaire F.,
Caumes E.
Publication year - 2014
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12097
Subject(s) - ivermectin , medicine , cutaneous larva migrans , hookworm infection , folliculitis , dermatology , surgery , helminthiasis , veterinary medicine , helminths , immunology , larva migrans
Background Treatment of hookworm‐related cutaneous larva migrans (Hr CLM ) with a single dose of oral ivermectin has not been adequately evaluated to date. Response rates reported in three large studies varied from 77% to more than 95%. Objectives We evaluated the efficacy of ivermectin in the treatment of Hr CLM . Methods We retrospectively studied all returning travellers with Hr CLM who consulted in our institution. Patients were then treated with a single, 200 μg/kg dose of ivermectin, orally. Results Sixty‐two travellers (35 female, 27 male, mean age 35.6 years) with Hr CLM and creeping dermatitis were included. Six patients (10%) also had associated hookworm folliculitis. Fifty‐nine patients (95%) completely responded with one ivermectin dose. The response rate was 98% in the 56 patients presenting with only creeping dermatitis and 66% in the six patients presenting with additional hookworm folliculitis ( P  = 0.02). Conclusion The efficacy of a single dose of oral ivermectin is higher in patients with only creeping dermatitis than in those with associated hookworm folliculitis.

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