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IL‐13: a marker of chromium contact allergy
Author(s) -
Martins L.E.A.M.,
Reis V.M.S.
Publication year - 2013
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1111/jdv.12005
Subject(s) - medicine , patch test , contact allergy , allergic contact dermatitis , allergy , immunology , contact dermatitis , nickel allergy , cytokine , lymphocyte , gold standard (test) , interleukin 4 , dermatology
Background Allergic contact dermatitis is a frequent, often disabling disease caused by countless substances. Patch testing remains the gold standard test to identify the causative agent; however, it is subjective, time‐consuming and not completely safe. Alternative methods were tried, but significant success has only been achieved with nickel. Objective Develop an alternative or complementary allergic contact dermatitis diagnostic test. Methods We compared the lymphocyte proliferative rate and cytokine production (IFN‐γ, IL‐2, IL‐4, IL‐5, IL‐10, IL‐12, IL‐13, IL‐17 and RANTES) between 18 chromium allergic patients and 19 controls. Results The lymphocyte proliferation test and some of the cytokines tested (IFN‐γ, IL‐2, IL‐5, IL‐12 and IL‐13) were able to discriminate allergic patients. However, striking results were only achieved using IL‐13, leading to an accuracy of about 90%. Conclusions If further studies confirm the data found, IL‐13 could be used as an alternative or complementary test to detect chromium contact allergy whereas lymphocyte proliferation test, IFN‐γ, IL‐2, IL‐5 and IL‐12 detections may serve as additional diagnostic tests.