Open AccessA pitfall in hemoglobin A1c measurement with high performance liquid chromatography method in the diagnosis of onset of fulminant type 1 diabetes mellitus
Author(s) -
Oe Yasuharu,
Anno Takatoshi,
Katsuhara Yukari,
Sugahara Ryo,
Kobayashi Miki,
Yakusue Mieko,
Tamura Masayo,
Kimura Yukiko,
Kawasaki Fumiko,
Kaku Kohei,
Kaneto Hideaki,
Kitanaka Akira
Publication year - 2022
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13834
Subject(s) - medicine , fulminant , diabetes mellitus , hemoglobin , type 2 diabetes mellitus , high performance liquid chromatography , chromatography , gastroenterology , pediatrics , endocrinology , chemistry
We showed a case with the onset of fulminant type 1 diabetes mellitus (FT1DM) whose HbA1c could not be measured with HPLC method. We think that the reason why his HbA1c was not be detected was associated with the presence of labile hemoglobin A1c (LHbA1c). These result mean that it is possible that LHbA1c can bring about a pitfall on HPLC method in diagnosis of onset of FT1DM.