Open AccessLongitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes
Author(s) -
Sato Tatsuya,
Miki Takayuki,
Furukawa Shinya,
Matsuura Bunzo,
Hiasa Yoichi,
Ohnishi Hirofumi,
Tanno Masaya,
Miura Tetsuji
Publication year - 2019
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13063
Subject(s) - medicine , dapagliflozin , type 2 diabetes , diabetes mellitus , interquartile range , qt interval , cardiology , retrospective cohort study , endocrinology
QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak‐Tend/QT in a subgroup with Tpeak‐Tend/QT?0.25 (median).