Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes | Zendy

Sato Tatsuya | Zendy; Miki Takayuki | Zendy; Furukawa Shinya | Zendy; Matsuura Bunzo | Zendy; Hiasa Yoichi | Zendy; Ohnishi Hirofumi | Zendy; Tanno Masaya | Zendy; Miura Tetsuji | Zendy

Open Access

Longitudinal impact of dapagliflozin treatment on ventricular repolarization heterogeneity in patients with type 2 diabetes

Author(s) -

Sato Tatsuya,

Miki Takayuki,

Furukawa Shinya,

Matsuura Bunzo,

Hiasa Yoichi,

Ohnishi Hirofumi,

Tanno Masaya,

Miura Tetsuji

Publication year - 2019

Publication title -

journal of diabetes investigation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.089

H-Index - 50

eISSN - 2040-1124

pISSN - 2040-1116

DOI - 10.1111/jdi.13063

Subject(s) - medicine , dapagliflozin , type 2 diabetes , diabetes mellitus , interquartile range , qt interval , cardiology , retrospective cohort study , endocrinology

QTc dispersion (QTcd) tended to be decreased at 24 weeks and was significantly decreased at 2 years after dapagliflozin treatment. In the subgroup with QTcd?53.7 ms (median), QTcd was significantly decreased at 24 weeks and remained improved for 2 years. Dapagliflozin also significantly reduced Tpeak‐Tend/QT in a subgroup with Tpeak‐Tend/QT?0.25 (median).

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