Open AccessClinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population
Author(s) -
Kurisu Seigo,
Sasaki Hideyuki,
Kishimoto Shohei,
Hirayasu Kazuhiro,
Ogawa Kinichi,
Matsuno Shohei,
Furuta Hiroto,
Arita Mikio,
Naka Keigo,
Nanjo Kishio,
Akamizu Takashi
Publication year - 2019
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13058
Subject(s) - medicine , prediabetes , diabetes mellitus , dyslipidemia , metabolic syndrome , nerve conduction velocity , population , obesity , impaired glucose tolerance , abnormality , cardiology , type 2 diabetes , endocrinology , environmental health , psychiatry
Aims/Introduction The prevalence of clinical polyneuropathies (Clin PN s) or nerve conduction abnormality ( NCA ) in the groups stratified by glucose tolerance, individual components of metabolic syndrome (metabolic syndrome [MetS] components: hypertension, dyslipidemia, obesity) and MetS defined by the International Diabetes Federation consensus was investigated in the Japanese general population. Factors associated with Clin PN and NCA were also identified. Materials and Methods A total of 625 examinees of regional medical checkup programs were recruited to this cross‐sectional study. Clin PN s were diagnosed by the Toronto Consensus. NCA was judged by at least one bilateral abnormality of sural nerve action potential amplitude or conduction velocity measured by a point‐of‐care nerve conduction device ( DPNC heck). Clinical factors associated with Clin PN s or NCA were examined by multiple logistic regression analysis. Deteriorating factors of sural nerve action potential amplitude or conduction velocity values were also investigated in participants without diabetes ( n = 550). Results As for glucose tolerance, Clin PN s or NCA significantly increased only in known diabetes patients compared with other groups. There was no difference between prediabetes and the normal group. The prevalence of Clin PN s and NCA was not significantly related to MetS or MetS’ components, except for frequent NCA in obesity. The factors significantly associated with both NCA and Clin PN s were smoking and known diabetes. In non‐diabetic participants, aging, tall height and hypertension were significant deteriorating factors of nerve conduction functions. Conclusions In Japan, Clin PN s and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS’ components. Smoking and known diabetes were factors significantly associated with Clin PN s or NCA . Hypertension might be a modifiable deteriorating factor of nerve function.