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Aims/Introduction  Emerging evidence has suggested that the genetic background of gestational diabetes mellitus ( GDM ) was analogous to type 2 diabetes mellitus. In contrast to type 2 diabetes mellitus, the genetic studies for  GDM  were limited. Accordingly, the aim of the present study was to extensively explore the influence of micro‐ribonucleic acid‐binding single‐nucleotide polymorphisms ( SNP s) in type 2 diabetes mellitus candidate loci on  GDM  susceptibility in Chinese.    Materials and Methods  A total of 839  GDM  patients and 900 controls were enrolled. Six micro‐ribonucleic acid‐binding  SNP s were selected from 30 type 2 diabetes mellitus susceptibility loci and genotyped using TaqMan allelic discrimination assays.    Results  The minor allele of three  SNP s,   PAX 4  rs712699 ( OR  1.366, 95% confidence interval 1.021–1.828,  P  = 0.036),   KCNB 1  rs1051295 ( OR  1.579, 95% confidence interval 1.172–2.128,  P  = 0.003) and   MFN 2  rs1042842 ( OR  1.398, 95% confidence interval 1.050–1.862,  P  = 0.022) were identified to significantly confer higher a risk of  GDM  in the additive model. The association between rs1051295 and increased fasting plasma glucose ( b  = 0.006,  P  = 0.008), 3‐h oral glucose tolerance test plasma glucose ( b  = 0.058,  P  = 0.025) and homeostatic model assessment of insulin resistance ( b  = 0.065,  P  = 0.017) was also shown. Rs1042842 was correlated with higher 3‐h oral glucose tolerance test plasma glucose ( b  = 0.056,  P  = 0.028). However, no significant correlation between the other included  SNP s (  LPIN 1  rs1050800,   VPS 26A  rs1802295 and   NLRP 3  rs10802502) and  GDM  susceptibility were observed.    Conclusions  The present findings showed that micro‐ribonucleic acid‐binding  SNP s in type 2 diabetes mellitus candidate loci were also associated with  GDM  susceptibility, which further highlighted the similar genetic basis underlying  GDM  and type 2 diabetes mellitus.

Micro‐ribonucleic acid‐binding site variants of type 2 diabetes candidate loci predispose to gestational diabetes mellitus in Chinese Han women