Open AccessMicro‐ribonucleic acid‐binding site variants of type 2 diabetes candidate loci predispose to gestational diabetes mellitus in Chinese Han women
Author(s) -
Wang Xiaojing,
Li Wei,
Ma Liangkun,
Ping Fan,
Liu Juntao,
Wu Xueyan,
Mao Jiangfeng,
Wang Xi,
Nie Min
Publication year - 2018
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12803
Subject(s) - gestational diabetes , single nucleotide polymorphism , medicine , diabetes mellitus , insulin resistance , type 2 diabetes mellitus , type 2 diabetes , endocrinology , confidence interval , pregnancy , genetics , genotype , biology , gestation , gene
Aims/Introduction Emerging evidence has suggested that the genetic background of gestational diabetes mellitus ( GDM ) was analogous to type 2 diabetes mellitus. In contrast to type 2 diabetes mellitus, the genetic studies for GDM were limited. Accordingly, the aim of the present study was to extensively explore the influence of micro‐ribonucleic acid‐binding single‐nucleotide polymorphisms ( SNP s) in type 2 diabetes mellitus candidate loci on GDM susceptibility in Chinese. Materials and Methods A total of 839 GDM patients and 900 controls were enrolled. Six micro‐ribonucleic acid‐binding SNP s were selected from 30 type 2 diabetes mellitus susceptibility loci and genotyped using TaqMan allelic discrimination assays. Results The minor allele of three SNP s, PAX 4 rs712699 ( OR 1.366, 95% confidence interval 1.021–1.828, P = 0.036), KCNB 1 rs1051295 ( OR 1.579, 95% confidence interval 1.172–2.128, P = 0.003) and MFN 2 rs1042842 ( OR 1.398, 95% confidence interval 1.050–1.862, P = 0.022) were identified to significantly confer higher a risk of GDM in the additive model. The association between rs1051295 and increased fasting plasma glucose ( b = 0.006, P = 0.008), 3‐h oral glucose tolerance test plasma glucose ( b = 0.058, P = 0.025) and homeostatic model assessment of insulin resistance ( b = 0.065, P = 0.017) was also shown. Rs1042842 was correlated with higher 3‐h oral glucose tolerance test plasma glucose ( b = 0.056, P = 0.028). However, no significant correlation between the other included SNP s ( LPIN 1 rs1050800, VPS 26A rs1802295 and NLRP 3 rs10802502) and GDM susceptibility were observed. Conclusions The present findings showed that micro‐ribonucleic acid‐binding SNP s in type 2 diabetes mellitus candidate loci were also associated with GDM susceptibility, which further highlighted the similar genetic basis underlying GDM and type 2 diabetes mellitus.