Open AccessPreventive effect of ipragliflozin on nocturnal hypoglycemia in patients with type 2 diabetes treated with basal‐bolus insulin therapy: An open‐label, single‐center, parallel, randomized control study
Author(s) -
Okajima Fumitaka,
Nagamine Tomoko,
Nakamura Yuko,
Hattori Naomi,
Sugihara Hitoshi,
Emoto Naoya
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12588
Subject(s) - medicine , hypoglycemia , insulin , type 2 diabetes , glycemic , diabetes mellitus , endocrinology , basal (medicine) , randomized controlled trial , gastroenterology
The efficacy of the administration of sodium‐glucose co‐transporter 2 inhibitor or the co‐administration of sodium‐glucose co‐transporter 2 inhibitor and dipeptidyl peptidase‐4 inhibitor to insulin therapy is not well known. A total of 58 patients with type 2 diabetes, admitted for glycemic control, were randomized to basal–bolus insulin therapy ( BBT ) alone or BBT plus 50 mg ipragliflozin and/or 20 mg teneligliptin. Insulin doses were adjusted to maintain normal blood glucose levels. Plasma glucose profiles were estimated by continuous glucose monitoring before discharge. Required insulin doses were not significantly different among the treatment groups. The frequency of nocturnal hypoglycemia was significantly lower in the groups treated with ipragliflozin (6.5 ± 10.6%) and ipragliflozin plus teneligliptin (6.9 ± 14.3%) than in the group treated with BBT alone (42 ± 43.6%). The administration of sodium‐glucose co‐transporter 2 inhibitor with or without dipeptidyl peptidase‐4 inhibitor prevented nocturnal hypoglycemia in type 2 diabetes patients with BBT .