Open AccessAdvanced glycation end‐products are a risk for muscle weakness in Japanese patients with type 1 diabetes
Author(s) -
Mori Hiroyasu,
Kuroda Akio,
Araki Michiko,
Suzuki Reiko,
Taniguchi Satoshi,
Tamaki Motoyuki,
Akehi Yuko,
Matsuhisa Munehide
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12582
Subject(s) - sarcopenia , medicine , diabetes mellitus , type 2 diabetes , glycation , skeletal muscle , muscle weakness , body mass index , weakness , ageing , type 2 diabetes mellitus , grip strength , endocrinology , pathological , physiology , surgery
Accumulation of advanced glycation end‐products ( AGE s) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence is a proposed marker for accumulation of AGE s in the skin. We aimed to investigate the relationship between AGE s accumulation, sarcopenia and muscle function of Japanese patients with type 1 diabetes. A total of 36 patients with type 1 diabetes participated in the present cross‐sectional study. Sarcopenia parameters (skeletal muscle mass index and knee extension strength) were compared with subcutaneous AGE s accumulation using skin autofluorescence. The prevalence of sarcopenia and impaired knee extension strength was 16.6% (men 0.0%, women 22.2%) and 47.2% (men 22.2%, women 55.6%), respectively. Knee extension strength was negatively correlated with skin autofluorescence ( r ² = 0.14, P < 0.05), but not with skeletal muscle mass index. In conclusion, the AGE s accumulation might be one of the reasons of impaired lower limb muscle function in Japanese patients with type 1 diabetes.