Open AccessLow osteocalcin level is a risk factor for impaired glucose metabolism in a Chinese male population
Author(s) -
Liang Yaojie,
Tan Aihua,
Liang Danyan,
Yang Xiaobo,
Liao Ming,
Gao Yong,
Jiang Yonghua,
Yao Ziting,
Lin Xinggu,
Lu Zheng,
Wu Chunlei,
Zhang Shijun,
Hu Yanlin,
Qin Xue,
Mo Zengnan,
Li Hong,
Zhang Haiying
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12439
Subject(s) - medicine , odds ratio , osteocalcin , endocrinology , impaired glucose tolerance , insulin resistance , diabetes mellitus , cohort , type 2 diabetes , confidence interval , population , carbohydrate metabolism , impaired fasting glucose , cross sectional study , cohort study , type 2 diabetes mellitus , biology , pathology , biochemistry , alkaline phosphatase , environmental health , enzyme
Aims/Introduction This study was to assess the association between serum osteocalcin level and glucose metabolism in a Chinese male population. Materials and Methods We carried out a cross‐sectional study with a cohort of participants from the Fangchenggang Area Male Health and Examination Survey. The cross‐sectional study was carried out among 2,353 men, including 2,139 participants with normal glucose tolerance, 148 with impaired fasting glucose and 66 with type 2 diabetes. A subsample of 1,109 men with measurement of osteocalcin was observed in the cohort. After a 4‐year follow‐up period, 1,049 non‐diabetic and 983 participants with normal glucose tolerance who submitted the available information were enrolled in the cohort. Participants were divided into group‐H (≥23.33 ng/ mL ) and group‐L (<23.33 ng/mL) by osteocalcin level. Results In the cross‐sectional study, osteocalcin levels were highest in participants with normal glucose tolerance, followed by those with impaired fasting glucose and type 2 diabetes ( P < 0.001). In partial correlation analysis adjusted for age, serum osteocalcin level was related to glucose level ( r = −0.082, P < 0.001), insulin level ( r = −0.079, P < 0.001) and insulin resistance ( r = −0.065, P = 0.002). Compared with group‐H, group‐L was associated with an increased risk of type 2 diabetes (odds ratio 2.107, 95% confidence interval 1.123–3.955), impaired fasting glucose (odds ratio 2.106; 95% CI 1.528–2.902), and insulin resistance (odds ratio 1.359, 95% confidence interval 1.080–1.710) adjusted for age, education levels, cigarette smoking and lipid profiles. In the cohort study, the increased risk of impaired fasting glucose was significant in group‐L vs group‐H (3.3% vs 1.2%, P = 0.026). Conclusions Low serum osteocalcin level was a risk factor for impaired glucose metabolism and subsequent type 2 diabetes.