Open AccessEvaluation of safety of insulin degludec on undergoing total colonoscopy using continuous glucose monitoring
Author(s) -
Takeishi Soichi,
Mori Akihiro,
Fushimi Nobutoshi,
Hachiya Hiroki,
Yumura Takayuki,
Ito Shun,
Shibuya Takashi,
Ohashi Noritsugu,
Kawai Hiromi
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12409
Subject(s) - medicine , morning , insulin degludec , insulin , hypoglycemia , endocrinology , diabetes mellitus , insulin glargine
Aims/Introduction There is little information regarding how to use insulin degludec (D) when diabetic patients are preparing for total colonoscopy ( TCS ). Materials and Methods A total of 12 patients with type 2 diabetes treated with insulin D and scheduled to undergo TCS were enrolled in the present study. A continuous glucose monitoring device was attached to each patient for 4 days, from two evenings before TCS to the morning after the procedure. The patients fasted for 24 h, starting after 18.00 h the day before TCS . Insulin D was only discontinued the morning of the day TCS was carried out. Results No patients experienced hypoglycemia during the daytime fasting period (08.00–18.00 h the day of TCS ); the hypoglycemic index, mean glucose level, and standard deviation were 0, 141.3 ± 31.5 mg/ dL and 15.6 ± 6.5 mg/ dL . The mean glucose level and standard deviation during the daytime fasting period were significantly lower than during the daytime control period (08.00–18.00 h the day before TCS ; P = 0.003, P = 0.001, respectively). The mean fasting glucose and fasting plasma glucose levels were significantly correlated ( r = 0.78, P = 0.002), as were both the mean glucose level and standard deviation during the daytime control period, and the change in the mean glucose level (fasting period minus control period; r = −0.79, P = 0.002, and r = −0.69, P = 0.01, respectively). Conclusions Patients can safely undergo TCS when insulin D is discontinued only once on the day of the procedure.