Open AccessAssociation of chemokine ligand 5/chemokine receptor 5 gene promoter polymorphisms with diabetic microvascular complications: A meta‐analysis
Author(s) -
Zhang Zhongwen,
Zhang Xiaoqian,
Dong Jianjun,
Gao Weiyi,
Liu Fupeng,
Zhao Junyu,
Wu Xiaoyun,
Guan Xiaoling,
Liu Ju,
Liao Lin
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12397
Subject(s) - odds ratio , medicine , meta analysis , genotype , confidence interval , chemokine receptor , chemokine , subgroup analysis , cc chemokine receptors , case control study , bioinformatics , oncology , receptor , gene , genetics , biology
Aims/Introduction Chemokine ligand 5 ( CCL 5) is a member of the CC ‐chemokine family expressed in various organs. It contributes to the migration of monocytes/macrophages into injured vascular walls by binding with its receptor chemokine receptor 5 ( CCR 5). Many studies have accessed the association between CCL 5/ CCR 5 gene promoter polymorphisms and diabetic microvascular complications ( DMI ). However, the results are conflicting and inconclusive. The aim of the present study was to evaluate the association more precisely. Materials and Methods Trials were retrieved through PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science and Cochrane database without restrictions on language. The pooled odds ratio ( OR ) and 95% confidence interval ( CI ) were used to describe the strength of association with DMI . Results Data were obtained from 11 case–control studies that included 2,737 DMI patients and 2,435 diabetic control subjects. In the overall analysis, the CCL 5‐403 G/A and CCL 5‐28 C/G gene polymorphisms were not significantly associated with the risk of DMI . However, CCR 5‐59029 G/A was an independent risk factor of DMI in a dominant model ( OR 1.77, 95% CI 1.06–2.97). Subgroup analysis showed that the risk of the CCR 5 59029A‐positive genotype was significant in Asians ( OR 2.08, 95% CI 1.68–2.57). In addition, the CCR 5 59029A‐positive genotype was associated with increased risk of albuminuria. Conclusions There were no associations of CCL 5 gene promoter polymorphism with the risk of DMI . However, the 59029A polymorphism in CCR 5 might affect individual susceptibility for DMI .