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Aims/Introduction  Increased levels of high‐sensitivity C‐reactive protein (hs‐ CRP ) likely leads to the development of atherosclerosis. Therefore, it is very important to know which factors largely influence hs‐ CRP  levels. In the present study, we examined the influence of various atherosclerosis‐related factors on hs‐ CRP  levels in patients with type 2 diabetes.    Materials and Methods  A total of 275 patients (176 men, 99 women) were enrolled in this study. We tested the relationship between the number of risk factors reaching a desired value and hs‐ CRP  levels. The Mann–Whitney  U ‐test was used to compare two groups. The Kruskal–Wallis test was used to carry out overall group comparisons, and the Steel–Dwass test was used to carry out between‐group comparisons. Spearman's rank correlation was carried out to study the correlation between hs‐ CRP  levels and clinical parameters. Multivariate regression method was used to analyze the factors independently contributing to hs‐ CRP  levels.    Results  Hs‐ CRP  levels were lower in patients with a larger number of risk factors reaching a desired value. In particular, triglyceride and body mass index ( BMI ) were independent risk factors determining hs‐ CRP  levels in a multivariate regression analysis. Furthermore, we compared the influence of various factors on hs‐ CRP  levels in both obese ( BMI  ≥25 kg/m 2 ) and non‐obese patients with type 2 diabetes ( BMI  <25 kg/m 2 ). In obese groups,  BMI  and urinary albumin were independent risk factors determining hs‐ CRP  levels, whereas triglyceride and statin were independent risk factors in non‐obese patients.    Conclusions  There is some difference in the factors responsible for hs‐ CRP  levels in obese and non‐obese patients with type 2 diabetes.

journal of diabetes investigation

Influence of atherosclerosis‐related risk factors on serum high‐sensitivity C‐reactive protein levels in patients with type 2 diabetes: Comparison of their influence in obese and non‐obese patients