Open AccessCorrelations of serum visfatin and metabolisms of glucose and lipid in women with gestational diabetes mellitus
Author(s) -
Liang Zhaoxia,
Wu Ying,
Xu Jianyun,
Fang Qin,
Chen Danqing
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12385
Subject(s) - medicine , gestational diabetes , endocrinology , insulin resistance , body mass index , lipid metabolism , diabetes mellitus , carbohydrate metabolism , insulin , hemoglobin , lipid profile , gestation , pregnancy , biology , genetics
Aims/Introduction Visfatin is a newly discovered adipocytokine hormone, which exerts an insulin‐like effect by binding to the insulin receptor‐1. However, the role of visfatin in human gestational diabetes mellitus ( GDM ) remains controversial. The purpose of the present study was to investigate the correlation between serum visfatin and metabolism of glucose and lipid in GDM . Materials and Methods This was a prospective study. A total of 38 GDM patients and 35 age‐ and body mass index‐matched controls were studied between J anuary 2012 and O ctober 2013. Fasting serum levels of visfatin, fasting plasma glucose, hemoglobin A 1c and lipid profile were measured. Two‐tailed t ‐tests and P earson's correlation coefficient were used to analyze the data. Results Perinatal visfatin levels were negatively correlated with fasting plasma glucose, insulin resistance index and triglycerides in controls ( r = −0.47, −0.51, −0.57, respectively; P < 0.05), and positively correlated with high‐density lipoprotein cholesterol ( r = 0.32, P < 0.05). A positive correlation with visfatin level only appeared in weight gain and body mass index in women with GDM ( r = 0.36, 0.45, respectively; P < 0.05). Conclusions Visfatin appears to be involved in glucose and lipid metabolism regulation and insulin resistance, suggesting a role in GDM pathogenesis.