Open AccessMetabolic parameters in type 2 diabetic patients with varying degrees of glycemic control during Ramadan: An observational study
Author(s) -
Siaw Melanie Y. L.,
Chew Daniel E. K.,
Toh Matthias P. H. S.,
Seah Darren E. J.,
Chua Ruimin,
Tan Jielin,
Lee Evonne Y. Q.,
Chan Sui Yung,
Lee Joyce Y. C.
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12374
Subject(s) - medicine , glycemic , glycated hemoglobin , diabetes mellitus , blood pressure , type 2 diabetes , metabolic control analysis , observational study , hemoglobin , cholesterol , endocrinology
Aims/Introduction The changes in metabolic parameters in type 2 diabetic patients who fast during Ramadan have not been studied in Singapore. This study aimed to examine the trends of glycated hemoglobin (HbA1c), systolic blood pressure, low‐density lipoprotein cholesterol, and triglycerides in diabetic patients with varying degrees of glycemic control and different types of therapeutic approaches during Ramadan. Methods The present retrospective study used a national electronic database to examine the metabolic parameter of Malay patients with type 2 diabetes. Eligible patients were stratified into three groups based on their mean HbA1c control before Ramadan: group 1 (HbA1c ≥10%), group 2 (HbA1c 7.1–9.9%) and group 3 (HbA1c ≤7%). Patients with a glomerular filtration rate <15 mL/min were excluded. The trends of metabolic parameters were traced before, during and after Ramadan. Results Of 13,565 patients examined, 5,172 patients (38.1%) were eligible for this study. Mean change of HbA1c varied from −1.4% to +0.2% during Ramadan, with the greatest reduction observed in group 1 ( P < 0.001). A minimal systolic blood pressure reduction was observed in groups 2 and 3 (2 mmHg; P < 0.01). Low‐density lipoprotein cholesterol and triglycerides changes were insignificant. A small, 0.1%, reduction in mean HbA1c was observed in patients taking oral antidiabetic agents during Ramadan ( P < 0.001). Conclusions Blood glucose was most affected during Ramadan, particularly in patients with mean baseline HbA1c ≥10%. The type of antidiabetic agent used did not seem to contribute to glycemic changes.