English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  Dipeptidyl peptidase‐4 inhibitors and glinides are effective in reducing postprandial hyperglycemia. However, little information is available on the comparative effects of the two drugs on the levels of postprandial glucose. The aim of the present study was to compare the effects of sitagliptin and nateglinide on meal tolerance tests in drug‐naïve patients with type 2 diabetes mellitus.    Materials and Methods  The study participants were 19 patients with type 2 diabetes mellitus, which was inadequately controlled by diet and exercise. An open‐label, prospective, cross‐over trial was carried out to compare the effects of single‐dose sitagliptin and nateglinide on the postprandial glucose level and its related hormones during meal tests.    Results  The change in area under the curve ( AUC ) of glucose from 0 to 180 min ( AUC  0–180 min ) during the meal test by nateglinide was similar to that by sitagliptin. As expected, the change in active glucagon like peptide‐1 was significantly higher after a single‐dose of sitagliptin than nateglinide. Then, insulin secretion relative to glucose elevation ( ISG ) (Δ ISG  0–180 min : Δ AUC  0–180 min  insulin/ AUC  0–180 min  glucose) was significantly enhanced by nateglinide compared with sitagliptin. Conversely, glucagon level (Δ AUC  0–180 min  glucagon) was increased by administration of nateglinide, whereas the glucagon level was reduced by administration of sitagliptin.    Conclusions  The effects of sitagliptin on postprandial glucose levels were similar to those of nateglinide in drug‐naïve type 2 diabetes patients. However, the induced changes in insulin, active glucagon‐like peptide‐1 and glucagon during meal loading suggest that reduction of postprandial hyperglycemia was achieved by the unique effect of each drug.

journal of diabetes investigation

Comparison of sitagliptin with nateglinide on postprandial glucose and related hormones in drug‐naïve Japanese patients with type 2 diabetes mellitus: A pilot study