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Aims/Introduction  We sought to determine the association between change in fasting plasma glucose ( FPG ) and levels of liver enzymes, such as aspartate transaminase, alanine transaminase and gamma‐glutamyltransferase, from health examinations.    Materials and Methods  A total of 9,393 health screen examinees with no evidence of viral hepatitis, liver diseases, abnormal liver function and diabetes in their past disease history were enrolled in the present study. All the participants underwent three health examinations. Group 1 and 4 were stationary groups of those with normal liver enzyme levels in the first and second health examinations ( G 1), and abnormal liver enzyme levels in the first and second health check‐up ( G 4). Groups 2 and 3 were altered groups of those with abnormal liver enzyme levels in the first health examination, which became normal in the second health examination ( G 2), and from a normal liver enzymes level to an abnormal liver enzymes level ( G 3).    Results   FPG  levels were elevated in male participants ( P  < 0.01), and were related to old age ( P  < 0.01), drinking ( P  < 0.01), smoking ( P  < 0.01) and so on. There was a strong relationship between  FPG  levels in the last health examination and altered liver function enzyme levels from the first health examination to the second check‐up. In other words, group 4 had the highest level of  FPG  compared with the other groups ( G 1 <  G 2 <  G 3).    Conclusions  An association was observed between  FPG  levels and abnormal liver function in manufacturing workers. Abnormal liver function can be closely associated with the development of diabetes.

Increasing risk of diabetes mellitus according to liver function alterations in electronic workers