Open AccessLow high‐density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes: Data from the H awaii– L os A ngeles– H iroshima study
Author(s) -
Hirano Masatoshi,
Nakanishi Shuhei,
Kubota Mitsunobu,
Maeda Shusaku,
Yoneda Masayasu,
Yamane Kiminori,
Kira Sakurako,
Sasaki Hideo,
Kohno Nobuoki
Publication year - 2014
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12170
Subject(s) - medicine , type 2 diabetes , hazard ratio , diabetes mellitus , confidence interval , body mass index , cholesterol , type 2 diabetes mellitus , risk factor , metabolic syndrome , high density lipoprotein , endocrinology , gastroenterology
Aims/Introduction A low level of high‐density lipoprotein cholesterol ( HDLC ) is a common feature of metabolic syndrome. We have reported that J apanese– A mericans who share a virtually identical genetic makeup with native J apanese, but who have lived W esternized lifestyles for decades, have lower HDLC levels and a high prevalence of type 2 diabetes compared with native J apanese. However, the impact of low HDLC level on type 2 diabetes is unclear. The aims of the present study were to evaluate whether serum HDLC level was associated with development of type 2 diabetes and if the effect might be modified by lifestyle. Materials and Methods We examined 1,133 non‐diabetic J apanese– A mericans and 1,072 non‐diabetic J apanese, who underwent the 75‐g oral glucose tolerance test ( OGTT ) and were followed for an average of 8.8 and 7.0 years, respectively. We analyzed whether serum HDLC level is a risk factor for development of type 2 diabetes based on the C ox proportional hazards model. Results After adjustment for age and sex, hazard ratios for development of type 2 diabetes per unit of serum HDLC level (mmol/L) were 0.292 (95% confidence interval [ CI ] 0.186–0.458, P < 0.0001) among J apanese– A mericans and 0.551 (95% CI 0.375–0.88, P = 0.0023) among native J apanese. Comparable hazard ratios after further adjustment for category of OGTT and body mass index were 0.981 (95% CI 0.970–0.993, P = 0.0018) and 0.991 (95% CI 0.980–1.002, P = 0.112), respectively. Conclusions HDLC level was associated with development of type 2 diabetes in both J apanese– A mericans and native J apanese. However, these results suggest that the impact of high‐density lipoprotein on glucose metabolism might be affected by lifestyle.