English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  In Japan, liraglutide was recently approved for patients with type 2 diabetes. To our knowledge, there are no markers predicting successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment. We therefore assessed clinical characteristics predicting successful switching.    Materials and Methods  We analyzed 21 patients with type 2 diabetes and estimated glomerular filtration rates <60 mL/min/1.73 m 2  receiving long‐term insulin in  S higa  U niversity of  M edical  S cience  H ospital,  O tsu,  S higa,  J apan. Their β‐cell function was assessed by measuring urinary  C ‐peptide and  C ‐peptide immunoreactivity ( CPR ) index, along with glucagon loading and oral glucose tolerance tests. Blood glucose concentration and blood pressure were measured daily before and after switching from insulin to liraglutide, and glycated hemoglobin ( H b A 1c;  N ational  G lycohemoglobin  S tandardization  P rogram) was assessed 12 weeks after switching to liraglutide.    Results  Baseline  H b A 1c was significantly lower in successfully switched than in unsuccessfully switched patients.  CPR  index, urinary  C ‐peptide concentration and 6‐min post‐glucagon increment in  CPR  (Δ CPR ) did not differ significantly in the two groups. Δ CPR  120 min after 75 g oral glucose was significantly higher in successfully than unsuccessfully switched patients. Mean blood glucose concentrations before breakfast, after breakfast, before lunch and after dinner were significantly lower in successfully switched patients.  H b A 1c did not change significantly in either group.    Conclusions  Measurement of oral glucose‐stimulated Δ CPR 120 min is recommended when considering switching Japanese type 2 diabetes patients with renal impairment from insulin to liraglutide monotherapy.

journal of diabetes investigation

Oral glucose‐stimulated serum  C ‐peptide predicts successful switching from insulin therapy to liraglutide monotherapy in Japanese patients with type 2 diabetes and renal impairment