Open AccessRole of peroxisome proliferator‐activated receptor gamma gene polymorphisms in type 2 diabetes mellitus patients of W est B engal, I ndia
Author(s) -
Pattanayak Arup Kumar,
Bankura Biswabandhu,
Balmiki Nisha,
Das Tapas Kumar,
Chowdhury Subhankar,
Das Madhusudan
Publication year - 2014
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12130
Subject(s) - peroxisome proliferator activated receptor gamma , odds ratio , medicine , type 2 diabetes mellitus , diabetes mellitus , endocrinology , confidence interval , type 2 diabetes , population , receptor , peroxisome proliferator activated receptor , environmental health
Aims/Introduction Peroxisome proliferator activated receptor gamma ( PPARG ) is a nuclear hormone receptor of the ligand‐dependent transcription factor involved in adipogenesis, and a molecular target of the insulin sensitizer, thiazolidinediones. The present study aimed to investigate whether the PPARG gene is associated with type 2 diabetes mellitus and its related traits within the population of W est B engal, I ndia. Materials and Methods The study participants (200 type 2 diabetes mellitus and 200 normal individuals) were chosen randomly, and the variants were screened by direct sequencing. Results The results showed that rs1801282 (odds ratio 0.66; 95% confidence interval 0.15–2.96; P = 0.57) and rs3856806 (odds ratio 1.23; 95% confidence interval 0.73–2.06; P = 0.44) variants of the PPARG gene were not associated with type 2 diabetes mellitus. Conclusions The results showed that the PPARG gene was not associated with type 2 diabetes mellitus in our study population. As the lack of association might come from the small sample size, further studies with larger sample size are required to verify the present observation.