Glucagon and insulin have opposite effects on tissue chromium distribution in an obese mouse model

Aims/Introduction Previous studies have suggested that chromium ( C r) is an essential cofactor for normal carbohydrate metabolism and affects insulin sensitivity, especially in rodent models. Several factors, such as insulin challenge, high carbohydrate intake, and response to stress (e.g., in obesity), alter C r excretion or distribution. Glucagon is known to regulate carbohydrate metabolism and hyperglucagonemia plays a role in the development of hyperglycemia in diabetic subjects. Materials and Methods In the present study we investigated possible modulation of C r levels by glucagon using an obese mouse model. Mice were kept on a high‐fat diet and then used as an obesity model. These obese mice were injected with one dose of glucagon or insulin and C r levels in their tissues were determined. Results In obese mice, glucagon challenge significantly increased C r levels in bone but decreased them in the fat and liver. In contrast, insulin challenge significantly decreased C r levels in bone but increased them in the fat, liver and muscle. Conclusions The results show that glucagon and insulin have opposite effects on C r levels in bone, fat, liver, and muscle.