Open AccessSerum adiponectin levels predict the risk of coronary heart disease in J apanese patients with type 2 diabetes
Author(s) -
Obata Yoshinari,
Yamada Yuya,
Kyo Mitsuaki,
Takahi Yasumitsu,
Saisho Kenji,
Tamba Sachiko,
Yamamoto Koji,
Katsuragi Kiyonori,
Matsuzawa Yuji
Publication year - 2013
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12078
Subject(s) - adiponectin , medicine , hazard ratio , quartile , type 2 diabetes , confidence interval , diabetes mellitus , population , proportional hazards model , cardiology , endocrinology , insulin resistance , environmental health
Aims/Introduction An inverse association between adiponectin and coronary heart disease ( CHD ) has been found in Caucasians, but it is uncertain whether this association can be extrapolated to the E ast A sian population. The present study aimed to investigate whether serum adiponectin levels can predict CHD in Japanese patients with type 2 diabetes as observed in C aucasians. Materials and Methods This longitudinal study included 504 patients with type 2 diabetes (342 men and 162 women) who were admitted to S umitomo H ospital between J uly 2005 and D ecember 2006. We used C ox proportional hazard analysis to estimate the hazard ratio ( HR ) of CHD associated with serum adiponectin levels at baseline. Results During a median follow up of 5.7 years (2177 person‐years), 40 participants had new CHD and 10 had recurrent CHD . After multivariate adjustment, the highest compared with the lowest quartile of serum adiponectin levels had a significantly reduced risk of CHD (hazard ratio [ HR ] 0.35; 95% confidence interval [ CI ] 0.13–0.94; P = 0.017). The multivariate adjusted HR for the risk of CHD according to a doubling of adiponectin at baseline was 0.61 (95% CI 0.39–0.97; P = 0.037). Conclusions High serum adiponectin levels are significantly associated with a lower risk of CHD in J apanese patients with type 2 diabetes. This association is independent of other well‐known CHD risk factors.