Open AccessOvarian morphology and prevalence of polycystic ovary syndrome in Japanese women with type 1 diabetes mellitus
Author(s) -
Miyoshi Arina,
Nagai So,
Takeda Masamitsu,
Kondo Takuma,
Nomoto Hiroshi,
Kameda Hiraku,
Hirai Amiko,
Cho Kyuyong,
Kimachi Kimihiko,
Shimizu Chikara,
Atsumi Tatsuya,
Miyoshi Hideaki
Publication year - 2013
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12040
Subject(s) - medicine , polycystic ovary , hyperandrogenism , type 2 diabetes mellitus , diabetes mellitus , endocrinology , glycated hemoglobin , dehydroepiandrosterone sulfate , population , androgen , type 2 diabetes , hormone , insulin resistance , environmental health
Aims/Introduction Polycystic ovary syndrome ( PCOS ) is a heterogeneous disorder including polycystic ovary morphology ( PCOM ), ovulatory dysfunction and hyperandrogenism. PCOS is frequently associated with type 2 diabetes mellitus; however, it is unknown whether PCOM and PCOS are prevalent in Japanese patients with type 1 diabetes mellitus. The purpose of our study was to determine the frequency of PCOM and PCOS in women with type 1 diabetes mellitus. Materials and Methods We evaluated clinical, hormonal and ovarian ultrasound data from 21 type 1 diabetes mellitus patients whose average glycated hemoglobin levels were 7.9 ± 1.5%. Results Ultrasound identified PCOM in 11 patients (52.4%) and these patients also had higher levels of the androgen dehydroepiandrosterone sulfate ( DHEA ‐S) than those without PCOM ( P < 0.05). Of the patients with PCOM , five presented menstrual irregularities (45.5%) and three met the Japanese criteria for PCOS (27.2%); whereas all patients without PCOM had a normal menstrual cycle ( P < 0.05). Conclusions Japanese premenopausal women with type 1 diabetes mellitus had a high frequency of PCOM as well as PCOS . This is the first research of this area carried out in an Asian population.