Open AccessCombined examination of glyceryl trinitrate‐mediated vascular dilation with flow‐mediated vascular dilation is essential for assessment of vascular function in type 2 diabetes
Author(s) -
Furuta Machi,
Ueyama Minoru,
Morita Shuhei,
Yamana Akiko,
Sanke Tokio
Publication year - 2013
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12021
Subject(s) - medicine , diabetes mellitus , cardiology , albuminuria , type 2 diabetes , vascular disease , vascular smooth muscle , endocrinology , smooth muscle
Aims/Introduction In order to characterize the impaired vascular function in type 2 diabetes ( DM ) patients, we evaluated the flow‐mediated vascular dilation ( FMD ) with glyceryl trinitrate‐mediated vascular dilation ( NMD ) using ultrasonography. Materials and Methods A total of 111 DM patients and 42 healthy control participants were studied. The maximal dilatation of FMD and NMD (% FMD and % NMD , respectively), the beginning time (T) of dilatation after stimulation and the velocity (V) of the vascular dilatation were also measured. Results Among DM patients, 49% had impaired % NMD , which affects the results of % FMD . In DM patients with normal % NMD , the % FMD was also significantly lower than that in control participants, although the T and the V were not impaired. In contrast, both the T and the V were disturbed in the DM patients with low % NMD . Multiple linear regression analysis showed that % NMD was independently correlated with albuminuria. Our results indicate that the impaired FMD in DM is be affected by low NMD , and impaired endothelial function already exists even in DM patients whose vascular smooth muscle function is still retained, and also albuminuria is the clinical feature of DM with low % NMD . Conclusions Examination of NMD , not only FMD , should be carried out as it offers the possibility of clarifying vascular function in DM patients.