Open AccessImpact of cigarette smoking on impaired insulin secretion and insulin resistance in J apanese men: The S aku S tudy
Author(s) -
Morimoto Akiko,
Tatsumi Yukako,
Deura Kijyo,
Mizuno Shoichi,
Ohno Yuko,
Watanabe Shaw
Publication year - 2013
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12019
Subject(s) - insulin resistance , medicine , insulin , diabetes mellitus , endocrinology , waist , triglyceride , metabolic syndrome , homeostatic model assessment , impaired glucose tolerance , body mass index , cholesterol
Aims/Introduction To assess the impact of smoking on impaired insulin secretion and insulin resistance in Japanese men. Materials and Methods This study included 1,199 men aged 30–79 years without diabetes, impaired insulin secretion and insulin resistance at baseline who underwent a comprehensive medical check‐up between A pril 2006 and M arch 2007 at S aku C entral H ospital. Smoking status was categorized as current, ex‐smoker and never‐smoker. Insulinogenic index and homeostasis model assessment‐insulin resistance were determined using a standard 75‐g oral glucose tolerance test. The Japan D iabetes S ociety criteria were used to define impaired insulin secretion and insulin resistance. Participants were followed up until M arch 2011. Results A total of 449 and 99 men developed impaired insulin secretion and insulin resistance during 3,403 and 4,092 person‐years follow up, respectively. The multivariable‐adjusted hazard ratios ( HR s) for impaired insulin secretion were 1.06 (95% confidence interval [ CI ] 0.84–1.33) in ex‐smokers and 1.95 (95% CI 1.44–2.63) in current smokers compared with never‐smokers after adjustment for age, familial history of diabetes, alcohol consumption, exercise, systolic blood pressure, triglyceride, γ‐glutamyltransferase, waist circumference, leukocyte count, changes in smoking status and changes in waist circumference. The number of pack‐years was positively associated with the risk for impaired insulin secretion in a dose‐dependent manner ( P ‐values for trend <0.001). The multivariable‐adjusted HR s for insulin resistance were 0.95 (95% CI 0.56–1.61) in ex‐smokers and 1.11 (95% CI 0.67–1.79) in current smokers compared with never‐smokers. Conclusions Cigarette smoking is a modifiable risk factor for impaired insulin secretion. The findings might also be important for other A sian populations, which have low insulin secreting ability.