Open AccessReplication study for the association of rs391300 in SRR and rs17584499 in PTPRD with susceptibility to type 2 diabetes in a J apanese population
Author(s) -
Imamura Minako,
Iwata Minoru,
Maegawa Hiroshi,
Watada Hirotaka,
Hirose Hiroshi,
Tanaka Yasushi,
Tobe Kazuyuki,
Kaku Kohei,
Kashiwagi Atsunori,
Kadowaki Takashi,
Kawamori Ryuzo,
Maeda Shiro
Publication year - 2013
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12017
Subject(s) - type 2 diabetes , odds ratio , single nucleotide polymorphism , insulin resistance , medicine , diabetes mellitus , population , genetic association , body mass index , genetic predisposition , type 2 diabetes mellitus , genome wide association study , disease , genetics , endocrinology , genotype , biology , gene , environmental health
Aims/Introduction Genetic risk variants for type 2 diabetes; rs391300‐G in SRR and rs17584499‐T in PTPRD , have been identified by a genome‐wide association study using H an C hinese individuals living in T aiwan. In an attempt to know the effects of these two variants in conferring susceptibility to type 2 diabetes in the J apanese, we carried out a replication study for the association of the two single nucleotide polymorphisms ( SNP s) with type 2 diabetes in a J apanese population. Materials and Methods We genotyped 11,530 J apanese individuals (8,552 type 2 diabetes patients and 2,978 controls) for rs391300 and rs17584499, and analyzed the association of these two SNP s with type 2 diabetes by logistic regression analysis. Results Neither of the variants was associated with susceptibility to type 2 diabetes in the Japanese population (rs391300‐G: odds ratio [ OR ] = 0.97; 95% confidence interval [ CI ] 0.91–1.04; P = 0.44; rs17584499‐T: OR = 1.04; 95% CI 0.96–1.14; P = 0.34). Adjustment or stratified analysis for age, sex and body mass index ( BMI ) did not affect the association of these variants with the disease. We did not observe a significant association of the SNP s with any metabolic traits, BMI , fasting plasma glucose, homeostasis model assessment of β‐cell function ( HOMA ‐β) and HOMA of insulin resistance ( HOMA ‐ IR ) ( P > 0.05). Conclusions Neither rs391300 nor rs17584499 had a significant effect on conferring susceptibility to type 2 diabetes in the J apanese population.