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Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series
Author(s) -
Spivey Justin,
Wrenn Rebekah,
Liu Beiyu,
Maziarz Eileen,
Kram Bridgette
Publication year - 2021
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13317
Subject(s) - enteral administration , medicine , oral administration , feeding tube , route of administration , cohort , parenteral nutrition , serum concentration , pharmacokinetics , gastroenterology , surgery
What is known and objective Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration. Case description Thirteen of 14 isavuconazole concentrations were >1 mg/dl (median 1.6 mg/dl) among those receiving enteral tube administration, which was comparable to intravenous (median 1.9 mg/dl). Higher concentrations were observed during oral administration (median 3 mg/dl). What is new and conclusion Administration of isavuconazole via tube resulted in concentrations comparable to FDA‐approved routes of administration. This route may be feasible and appropriate for select patients.