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Impact of changing reimbursement criteria on statin treatment patterns among patients with atherosclerotic cardiovascular disease or cardiovascular risk factors
Author(s) -
Hsu ChiaYun,
Chen WenJone,
Chen HoMing,
Tsai HsinYi,
Hsiao FeiYuan
Publication year - 2021
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13299
Subject(s) - medicine , statin , discontinuation , reimbursement , diabetes mellitus , cohort , atherosclerotic cardiovascular disease , disease , physical therapy , endocrinology , health care , economics , economic growth
What is known and objective Starting 1 August 2013, the eligible cholesterol level for statin reimbursement in patients with atherosclerotic cardiovascular disease (ASCVD) or cardiovascular disease (CVD)‐related risk factors changed from LDL‐C ≥ 130 mg/dl (or TC ≥ 200 mg/dl) to LDL‐C ≥ 100 mg/dl (or TC ≥ 160 mg/dl) in Taiwan, which may modify clinician prescribing behaviours. We aimed to evaluate the impact of changing reimbursement criteria on statin treatment patterns. Methods A before–after cohort design was conducted using Taiwan's National Health Insurance Research Database. Differences in statin treatment patterns between the pre‐ and postregulation periods were compared. Two prespecified study cohorts were identified to examine the impacts of this change on those who need statins for “secondary prevention” (patients newly diagnosed with ASCVD) and those who need statins for “primary prevention” (patients newly diagnosed with CVD‐related risk factors, such as diabetes mellitus [DM]). Treatment patterns measured in this study included initiation, discontinuation, switching, dose increase, dose decrease and dose maximization. Results The proportion of patients who initiated statins during the postregulation period was higher than that of patients who initiated statins during the preregulation period (eg coronary heart disease (CHD) patients, pre‐ vs. postregulation: 41.23% vs. 48.25%). Notably, only 30%‐40% of patients initiated statin use in the postregulation period across different conditions. In addition, the proportion of patients who discontinued statins remained very high. Even in the postregulation period, more than half of CHD patients discontinued statins during the 1‐year follow‐up period (eg CHD patients, pre‐ vs. postregulation: 59.07% vs. 52.75%). What is new and conclusion The new reimbursement criteria started on 1 August 2013 seemed to lower the barriers of access to the first statin prescription among patients with CHD, cerebrovascular disease (CBVD) and DM. Nevertheless, the proportion of patients who initiated statin use was suboptimal, and the proportion of patients who discontinued statins was very high in the postregulation period.