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Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus‐associated acute respiratory distress syndrome in paediatric patients— a case series
Author(s) -
Le Thao K.,
Brown Brian K.,
Namtu Katie C.,
Berman David M.,
Kiskaddon Amy L.
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13244
Subject(s) - cidofovir , ards , extracorporeal membrane oxygenation , medicine , dosing , respiratory distress , acute respiratory distress , anesthesia , surgery , pediatrics , lung , virus , virology
What is known and objective Reports of cidofovir dosing with extracorporeal membrane oxygenation (ECMO) support are limited. This case series describes our clinical experience and provides a literature review regarding cidofovir dosing in paediatric patients requiring ECMO support. Case summary Three patients with adenovirus‐associated acute respiratory distress syndrome (ARDS) were treated with cidofovir while requiring ECMO support. A 27‐month‐old patient was treated with cidofovir 1 mg/kg/dose three times weekly, and a 19‐month‐old patient and an 18‐year‐old patient were treated with cidofovir 5 mg/kg/dose weekly. What is new and conclusion This case series describes the dosing and positive clinical response of cidofovir in paediatric patients with adenovirus‐associated ARDS requiring ECMO support.