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Non‐occlusive ST‐segment elevated myocardial infarction following the administration of liposomal amphotericin B in the treatment of cryptococcal meningitis
Author(s) -
Kullab Susan M.,
Patel Paras D.,
Lewis Paul O.
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13109
Subject(s) - medicine , cryptococcal meningitis , myocardial infarction , amphotericin b , chest pain , st segment , meningitis , cardiology , adverse effect , anesthesia , surgery , antifungal , dermatology , immunology , viral disease , virus
What is known and objective Liposomal amphotericin B (L‐AmB) is the cornerstone of many serious invasive fungal infections. Despite lower frequencies of commonly reported adverse events in clinical trials compared to conventional formulations, post‐marketing complications continue to mount. Case description We present a case of chest pain following the initial dose of L‐AmB for cryptococcal meningitis. Electrocardiogram demonstrated no acute electrocardiogram findings. Upon rechallenge, the chest pain worsened was subsequently accompanied by ST‐segment elevation. Emergent coronary angiography found no acute findings. What is new and conclusion Providers should be aware of cardiac complications with L‐AmB, including non‐occlusive ST‐segment elevation.