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Cannabinoids for drug‐resistant seizures in a critically ill patient—Case report and literature review
Author(s) -
Capra Stefania,
Narayan Sujita W.,
Parratt Kaitlyn,
Patanwala Asad E.
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13082
Subject(s) - cannabidiol , medicine , critically ill , intensive care unit , intensive care medicine , drug resistant epilepsy , mechanical ventilation , coma (optics) , epilepsy , drug , critical illness , anesthesia , psychiatry , cannabis , physics , optics
What is known and objective Drug‐resistant seizures are life‐threatening and contribute to sustained hospitalization. We present the case of a critically ill 28‐year‐old male with Lennox‐Gastaut syndrome who had approximately 30 seizures/day in the intensive care unit. Case description Patient required mechanical ventilation and pharmacologically induced thiopentone coma. He was commenced on cannabidiol and subsequently extubated. He remained seizure‐free thereafter on a combination of cannabidiol and anti‐epileptic medication that predated his critical illness. What is new and Conclusion Our case report provides a unique perspective on the role of cannabidiol in achieving remission from drug‐resistant seizures in critically ill patients.