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A case of idiosyncratic liver injury after oxaliplatin‐induced thrombocytopenia
Author(s) -
Honda Shinji,
Tsujimoto Masayuki,
Minegaki Tetsuya,
Mori Tomohiko,
Muraoka Junji,
Nishiguchi Kohshi
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13068
Subject(s) - oxaliplatin , liver injury , medicine , liver failure , pharmacology , surgery , colorectal cancer , cancer
What is known and objective Oxaliplatin is a platinum drug used for treating digestive cancers that can lead to drug‐induced thrombocytopenia (DITP). We report a case of oxaliplatin‐induced anaphylaxis and DITP, complicated by idiosyncratic drug‐induced liver injury (IDILI). Case summary A 46‐year‐old woman with rectal cancer developed anaphylaxis shortly after oxaliplatin administration (post‐operative CapeOX), presenting with low platelet count (0.2 × 10 4 /µL) and elevated aspartate aminotransferase (1091 IU/L) and alanine aminotransferase (1010 IU/L) by day 10. Following 50 mg/d prednisolone administration from day 9, she left the hospital on day 36 after recovering. What is new and conclusion This is the first case report of oxaliplatin‐induced IDILI and its effective treatment with steroids.