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Reversible black tongue: A little known side effect of imipenem/cilastatin and evidence for novel mode of action
Author(s) -
Zhao Shujuan,
Fan Lei,
Feng Jing,
Ma Peizhi
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13066
Subject(s) - tongue , cilastatin , imipenem , medicine , limiting , imipenem/cilastatin , ingestion , side effect (computer science) , anesthesia , antibiotics , surgery , pathology , biology , microbiology and biotechnology , mechanical engineering , antibiotic resistance , computer science , programming language , engineering
What is known and objective Black tongue syndrome (BT) is a rare and self‐limiting disorder which can result from physiological and metabolic condition and ingestion of toxic substances. Medications are the most common cause of BT. Case summary A 39‐year‐old male patient presented with BT after the initiation of imipenem/cilastatin. Within one week of cessation of these drugs, the patient's tongue returned to a normal colour. What is new and conclusion This is the first case of BT induced by imipenem/cilastatin. Withdrawal of the combination is likely to reverse the condition.