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N‐acetylcysteine and ascorbic acid therapy for acute hepatic injury after hexavalent chromium ingestion
Author(s) -
Yu JiunHao,
Lu JianXun,
Smollin Craig,
Cheng HaoTsai,
Seak ChenJune,
Chen HsienYi
Publication year - 2020
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13044
Subject(s) - hexavalent chromium , ingestion , ascorbic acid , acetylcysteine , medicine , chromium , gastroenterology , chemistry , biochemistry , food science , antioxidant , organic chemistry
Abstract What is known and objective Hexavalent (VI) chromium is a powerful oxidant that can produce cellular oxidative stress and multi‐organ system dysfunction. The role of antioxidants such as N‐acetylcysteine (NAC) and ascorbic acid in alleviating organ damage in humans remains unclear. Case description We present a 47‐year‐old male who ingested 30 mL of plating solution and developed hepatic injury. He was treated with NAC and ascorbic acid with improvement in hepatic function. However, his clinical conditions and jaundice worsened again after discontinuing these therapies. What is new and conclusion Our findings suggest a potential role for antioxidant therapy for acute hexavalent chromium poisoning.