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Doxycycline: An option in the treatment of ulcerated oral lesions?
Author(s) -
Piacentini Marcello,
Borghetti Ruchielli Loureiro,
Zancanaro de Figueiredo Maria Antonia,
Cherubini Karen,
Gonçalves Salum Fernanda
Publication year - 2019
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13022
Subject(s) - medicine , doxycycline , stomatitis , mucositis , placebo , dermatology , clinical trial , herpes labialis , recurrent aphthous stomatitis , randomized controlled trial , oral medicine , cochrane library , surgery , chemotherapy , dentistry , antibiotics , pathology , alternative medicine , immunology , virus , herpes simplex virus , microbiology and biotechnology , biology
What is known and objectives In addition to its antimicrobial effect, doxycycline has potent anti‐inflammatory activity. In view of these pharmacological characteristics, its use in the management of inflammatory, autoimmune and granulomatous diseases has been proposed. The objective of this study was to investigate, through a systematic literature review, the effect of doxycycline on pain and healing of ulcerated lesions of the mouth. Methods An electronic search was performed in accordance with PRISMA guidelines in PubMed, Cochrane Central Register, Web of Science, Bireme/LILACS and Scopus databases. Controlled, randomized clinical trials were selected. The concentration of doxycycline, frequency of application, pain relief and clinical remission of the lesions were analysed. Results and discussion According to the inclusion criteria, five articles were selected. In four of these studies, doxycycline was used in the treatment of aphthous stomatitis, and in one study, it was used in the treatment of herpes labialis. In all studies, the drug was used topically, both as a hydrogel and as a crushed tablet (along with a prosthetic adhesive). The groups treated with doxycycline showed faster healing of lesions and lower pain scores compared to placebo. What is new and conclusion The present study suggests that topical doxycycline has a positive effect on the treatment of recurrent aphthous ulceration and herpes labialis. Experimental animal studies and double‐blind randomized clinical trials should be performed on other oral lesions, such as traumatic ulcers and mucositis.