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Marked change in blood tacrolimus concentration levels due to grapefruit in a renal transplant patient
Author(s) -
Zhai Xingyu,
Chen Chaoyang,
Xu Xin,
Ma Lingyue,
Zhou Shuang,
Wang Zhiqi,
Ma Lingyun,
Zhao Xia,
Zhou Ying,
Cui Yimin
Publication year - 2019
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.13002
Subject(s) - tacrolimus , grapefruit juice , renal transplant , medicine , blood concentration , pharmacology , kidney , transplantation , pharmacokinetics
What is known and objective Reveal the current status of grapefruit in the Chinese medical environment. Case description An approximately 2‐fold increase in blood tacrolimus concentration was observed on day 9 in the hospital despite no change in dose. The only possible cause is that the patient had consumed grapefruit during hospitalization, which is often mistakenly considered to be a fruit belonging to the West and uncommon in the medical environment in China. What is new and conclusion This is the first report of grapefruit‐induced blood tacrolimus concentration change. Chinese medical practitioners should re‐evaluate the impact of grapefruit and food‐drug interactions caused by it.