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Aspirin resistance mediated by oxidative stress‐induced 8‐Isoprostaglandin F2
Author(s) -
Guo Juan,
Wang Jue,
Feng Juan
Publication year - 2019
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12838
Subject(s) - oxidative stress , aspirin , pharmacology , oxidative phosphorylation , medicine , chemistry , biology , biochemistry
Summary What is Known and Objective Aspirin resistance refers to a patient's poor response to aspirin. There are many factors that can contribute to aspirin resistance, including single‐nucleotide polymorphisms, medication compliance, drug‐drug interactions and inflammation. Comment Recently, oxidative stress‐induced 8‐isoprostaglandin F2α has attracted considerable attention because it is considered as a mechanism of aspirin resistance in many diseases, including coronary artery disease, neurology system disease, metabolic syndrome, cancer, chronic obstructive pulmonary disease and chronic kidney disease. In these diseases, increased oxidative stress may promote platelet activation and reduce the efficacy of aspirin by producing excessive amounts of 8‐isoprostaglandin F2α. What is New and Conclusion Given the wide clinical use of aspirin, it is essential to understand why some patients do not response to it. This article reviews current research on aspirin resistance mediated by oxidative stress‐induced 8‐isoprostaglandin F2α.