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Drug‐drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report
Author(s) -
Yoshikawa Naoki,
Tazaki Tomoya,
Hatanaka Mari,
Oda Yasuharu,
Matsumoto Nobuhiro,
Sonoda Junichiro,
Ikeda Ryuji
Publication year - 2019
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12764
Subject(s) - phenytoin , drug , medicine , phenobarbital , epilepsy , drug interaction , pharmacology , psychiatry
Summary What is known and objective Multi‐drug combinations often make chemotherapy difficult owing to drug‐drug interactions (DDIs). We report a rare and difficult‐to‐treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs. Case description A 70‐year‐old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment. What is new and Conclusion We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.