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Paralysis of the external popliteal sciatic nerve associated with daptomycin administration
Author(s) -
Villaverde Piñeiro L.,
Rabuñal Rey R.,
García Sabina A.,
Monte Secades R.,
García Pais M. J.
Publication year - 2018
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12666
Subject(s) - medicine , adverse effect , daptomycin , paralysis , sciatic nerve , peripheral neuropathy , anesthesia , surgery , vancomycin , endocrinology , biology , bacteria , genetics , diabetes mellitus , staphylococcus aureus
Summary What is known and objective Peripheral neuropathy has been associated with the administration of certain drugs. Few reports have described the association of daptomycin with the development of peripheral neuropathy, none of them with peroneal nerve involvement. Case summary We report a case of a 62‐year‐old man who developed external popliteal sciatic nerve paralysis after 22 days of therapy with daptomycin. What is new and conclusion: We present an uncommon and not previously reported adverse event. We have also analysed a possible alteration in a metabolic pathway ( ABCB1 gene polymorphisms) that, in some patients, could explain certain drug adverse events. What is new and conclusion We present an uncommon and not previously reported adverse event. We have also analysed a possible alteration in a metabolic pathway ( ABCB1 gene polymorphisms) that, in some patients, could explain certain drug adverse events.