Premium
Liver injury induced by clomiphene citrate: A case report and literature reviews
Author(s) -
Zhang H.M.,
Zhao X.H.,
He Y.F.,
Sun L.R.
Publication year - 2018
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12654
Subject(s) - medicine , clomifene , discontinuation , liver injury , abdominal pain , ovulation , gastroenterology , ovulation induction , hormone
Summary What is known and objective Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. Case summary A 31‐year‐old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish‐brown urine and upper abdominal pain. The levels of aspartate aminotransferase ( AST ) and alanine aminotransferase ( ALT ) were elevated. Based on the subsequent examination, he was diagnosed with liver injury and cholecystitis. The levels of AST and ALT returned to normal range after discontinuation of clomiphene citrate and symptomatic treatment. What is new and conclusion The mechanism of liver injury caused by clomiphene citrate is still unclear. Polymorphism of CYP 2D6 may have had an effect. Liver function tests should be performed when there is upper abdominal pain after administration of clomiphene citrate.