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Diabetes insipidus after discontinuation of vasopressin infusion for septic shock
Author(s) -
Rana H.,
Ferguson N.,
Dicpinigaitis P. V.
Publication year - 2018
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12627
Subject(s) - discontinuation , diabetes insipidus , medicine , vasopressin , septic shock , polyuria , hypernatremia , anesthesia , pediatrics , incidence (geometry) , shock (circulatory) , intensive care medicine , sepsis , surgery , diabetes mellitus , endocrinology , chemistry , physics , organic chemistry , sodium , optics
Summary What is known and objective Despite widespread use of vasopressin for the treatment of septic shock, few cases of diabetes insipidus (DI) following its discontinuation have been reported. Case summary A 54‐year‐old man presented with pneumonia progressing to septic shock, requiring norepinephrine and vasopressin for refractory hypotension. After clinical improvement, the patient on 3 separate occasions developed polyuria and severe hypernatremia upon discontinuation of vasopressin, with prompt recovery upon its resumption. What is new and conclusion Occurrence of DI upon discontinuation of vasopressin infusion appears to be rare, but incidence may be underestimated due to a paucity of published reports. Actual incidence and underlying mechanism of this phenomenon remain to be elucidated.